Australasian childhood longitudinal studies: Exciting yet challenging times

New and complex strabismus surgeries: exciting times!

Strabismus surgeries have, in recent times, progressed at a rapid rate, with the introduction of a multitude of remarkable techniques that have defied the rules of classic surgery. With the advent of newer imaging modalities, and a better understanding of disease pathophysiology, surgical techniques are more targeted toward the specific muscles involved and its pathology. This article endeavors...

Synaptic transmission: Exciting times for presynaptic receptors

Presynaptic receptors play an important role - typically inhibitory--in modulating the strength of synaptic transmission in the brain. Recent studies now reveal that neurotransmitters can enhance synaptic strength by activating ligand-gated ion channels in presynaptic nerve endings.

polycystic ovary syndrome: an apparently simple yet challenging diagnosis

Quality care in challenging times.

Every 72 seconds, someone in the United States develops Alzheimer's disease, an incurable affliction that kills at least 66,000 people annually, making it the nation's seventh leading cause of death. Alzheimer's is the most common form of dementia, accounting for 60 percent of cases (5.1 million people), according to the Alzheimer's Association, Chicago. Dementia describes a group of symptoms--...

An exciting but challenging road ahead for computational enzyme design.

Recent work has demonstrated that computational enzyme design can generate active catalysts. Although the progress is encouraging, the future will be brighter for this new field if its current limitations and the challenges which must be overcome are as broadly understood as its promise. This essay compares the activities of de novo designed enzymes to those of naturally occurring enzymes and h...